Toxins
that cause rare disease are erratic
Necrotizing fasciitis is a rare flesh-eating
infection that can be caused when common bacteria
such as streptococcus and clostridia produce
and release rogue toxins in a person's body.
The toxins can cause small clots to form in
blood vessels. Skin and muscle tissues fed by
those vessels then die from lack of blood.
If enough toxins are released and enough tissue
dies, the body goes into shock, and basic functions
like breathing, blood pressure and heart rate
can falter.
Nebraska State Epidemiologist Tom Safranek
said the toxins that cause necrotizing fasciitis
are rare and sporadic. Common bacteria only
rarely develop the ability to produce the toxins.
And the same toxic strain may have far less
serious consequences in one person than in another.
The only type of flesh-eating infections Nebraska
tracks are those caused by streptococcus, which
is different from what Ashley Munson has.
Safranek said the state has had one reported
case so far this year, and one case last year.
Both were caused by a group A streptococcus
bacteria, one of the most common causes of strep
throat and minor infections.
Exactly why one Nebraskan becomes deathly ill
from a type of bacteria that in most causes
only a sore throat is unclear.
"It's a combination of something going
on in the patient and something going on in
the bug," Safranek said. "If the bug
doesn't have the ability to produce the toxin,
it's not going to cause necrotizing fasciitis.
And, even if the toxin's present in the bug,
there are what we call host factors in the patient.
Maybe a patient has a greater immunity or got
antibiotics early or cleaned the wound more
quickly. They are not a good host for whatever
reason."
According to the Merck Manual of Medical Information,
about one in three people who develop necrotizing
fasciitis die from it, even with appropriate
care. Treatment includes intravenous antibiotics,
surgical removal of dead tissue (including limb
amputation) and supportive care.
But if the infection is advanced, even those
measures don't always work.
"Antibiotic resistance isn't usually the
problem," Safranek said. "The issue
is by the time they get medical attention, the
patients are generally so sick, the antibiotics
won't work."
Safranek said the best way to lower your risk
of developing necrotizing fasciitis or other
invasive infections is good wound hygiene: Clean
even minor cuts, scrapes and skin injuries with
soap and water. Apply an antibiotic cream or
ointment. And cover the wound until it heals.